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MIF demonstrates chemokine-like functionality and was determined to be a ligand of the two CXCR2 and CXCR4. Binding of MIF to these receptors improves monocyte recruitment and leukocyte chemotaxis (Figure one). In human chondrosarcoma cells, this recruitment is mediated by Gαi proteins and PI3K in T cell adhesion by upregulation of the transcripti